Presented by Alger
Medicine    October 1, 2014
New Drugs Silence Genes
Posted by Kevin Bullis

Hepatitis B and high cholesterol could soon be a thing of the past. A new drug is currently in human trials that silence genes responsible for these and other diseases.

The disease starts with a feeling of increased clumsiness. Spilling a cup of coffee. Stumbling on the stairs. Having accidents that are easy to dismiss—everyone trips now and then.

But it inevitably gets worse. Known as familial amyloid polyneuropathy, or FAP, it can go misdiagnosed for years as patients lose the ability to walk or perform delicate tasks with their hands. Most patients die within 10 to 15 years of the first symptoms.

There is no cure. The disease is caused by malformed proteins produced in the liver, so one treatment is a liver transplant. But few patients can get one—and it only slows the disease down.

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